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Although not considered a change in structure to the BBB per se, endothelial cells can increase leukocyte adhesion molecule expression leading to increased leukocyte extravasation into the brain parenchyma under pathological conditions [58, 59]

PMID 41476424

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[1] [2] Semaglutide works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, and reduces appetite