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Circulation Population Health And Outcomes 2018, 11: e005180

In addition, tumor cells in the bone metastatic niche hijacked VCAM1 + CD163 + CCR3 + macrophages of the erythroblastic islands, which usually supply iron to erythroblasts, disrupting iron homeostasis within the hematopoietic niche, impairing erythropoiesis and contributing to cancer-associated anemia [75]

The same targeting mechanism allowed for selective delivery of ferroptosis inhibitors to the affected coronary territory, demonstrating superior cardioprotection compared to systemic therapy in experimental coronary occlusion models