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Multifunctional metabolic enzymes in mitochondrial regulation: initiating signals of drug resistance in CRC Within the complex metabolic adaptation network of CRC, certain conventional metabolic enzymes are increasingly recognized as critical regulatory nodes that link energy flux to therapeutic response, owing to their moonlighting properties, which involve multiple non-canonical functions beyond their enzymatic roles [94]

thaliana by cauliflower mosaic virus (CaMV), systemic induction of GST1 was associated with increased virus titers and the development of disease symptoms (Love et al., 2005)