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Description

NTRK1 and NTRK3) but the expression level of the fusion gene is often markedly higher than that of the native kinase, and strong high intensity staining for the kinase domain of these proteins is predictive of the presence of a gene fusion

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The first and rate-limiting step is catalyzed by the enzyme glutamate-cysteine ligase (GCL), which fuses glutamate and cysteine

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