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Mechano Growth Factor (MGF) is produced by skeletal muscle in response to mechanical loading, eccentric exercise, or injury through alternative splicing at exon 5 of the IGF-1 gene, generating a C-terminal extension peptide (the Ec peptide) that is unique to MGF and absent from systemic IGF-1

Liraglutide, a glucagon-like peptide-1 receptor agonist, facilitates osteogenic proliferation and differentiation in MC3T3-E1 cells through phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), extracellular signal-related kinase (ERK)1/2, and cAMP/protein kinase A (PKA) signaling pathways involving beta-catenin

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