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Histone demethylase KDM3B enhances SLC7A11 expression by inhibiting H3K9 methylation [34]

doi: 10.1038/s41556-018-0271-4 209 VeresAFaustALBushnellHLEngquistENKentyJHRHarbGet al

Therefore, targeting Gln metabolism within the TME may inhibit the development of an immunosuppressive environment and improve the efficacy of immunotherapy