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The phase 2 trial published in The New England Journal of Medicine in 2023 enrolled adults with obesity without type 2 diabetes and demonstrated dose-dependent weight loss of up to 24.2% of body weight at the highest dose over 48 weeks results that attracted considerable scientific and media attention

Many of the FDA advisors and internal staff who oversaw those decisions no longer work for the agency

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But the body does not exclusively burn fat when calories drop that dramatically