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This story was originally published by Men's Fitness on Jul 1, 2026, where it first appeared in the Nutrition section

For comprehensive anti-aging goals, sermorelin is often considered the primary choice because: It aligns with natural hormone rhythms and sleep-based GH release It has a longer clinical history and prior FDA-approved status It supports sustained pituitary function over time Sleep improvement is typically rapid and pronounced However, ipamorelin offers advantages when anti-aging goals are focused on body composition, recovery, and maintaining a clean hormonal profile

PI3KAkteNOS signaling raises nitric oxide in afferent arterioles, blunting hyperfiltration in the diabetic kidney [16]