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The Importance of Metabolism Besides dose, what your body does with a particular substance, how it gets metabolized and the biologic effect those metabolites exert are all critical factors in determining if that substance is truly friend or foe

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While BCL-2 protein expression upon CB-839 treatment remained stable even at maximal concentrations of 100 M, MCL-1 protein levels increased in both cell lines in cells incubated with CB-839 compared with control cells, indicating that the HG-3 and MEC-1 cells had an MCL-1 protein dependency in response to apoptotic stimuli ( Supplemental Figure 3 )

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