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4.1 The ApelinAPJ axis Apelin was identified as the endogenous ligand for the APJ receptor, a G proteincoupled receptor structurally related to the angiotensin II type 1 receptor but functionally distinct from the reninangiotensin system ( Despite these favorable metabolic effects, enthusiasm for apelin-based therapeutics waned due to its potent cardiovascular actions, including vasodilation and positive inotropy

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Source: rootanalysis.com Patent Expiry A Key Trigger Patent expiration, often termed the patent cliff, presents a crucial turning point in the life cycle of blockbuster drugs

Subtype-directed care holds particular promise in infertility management, where aligning surgical, medical, and ART strategies to endometriosis phenotype can significantly improve reproductive outcomes while minimizing iatrogenic risks