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Where tirzepatide is a dual agonist (GLP-1 + GIP), retatrutide is a triple agonist (GLP-1 + GIP + glucagon receptor)
Colon cancer, the second leading cause of cancer deaths in the United States, begins in the large intestine
Semaglutide at 31 amino acids sits in a middle range, large enough to have complex receptor interactions, small enough to be synthesized and modified with precision
Combining with DPP-4 inhibitors is generally not recommended, as both drug classes work on the incretin system Adding basal insulin for those with more significant hyperglycaemia, which can be used alongside GLP-1 medications (with careful monitoring for hypoglycaemia) Switching to insulin therapy entirely may be necessary for those with advanced beta cell failure For weight management , when GLP-1 medications don't produce adequate weight loss, alternatives include: Orlistat , a lipase inhibitor that reduces fat absorption, though weight loss is typically modest (2-3 kg on average) Naltrexone-bupropion (Mysimba), which works on appetite centres through different pathways
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