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TOP 5: Farxiga (Dapagliflozin) 2023 Sales: $5.963 billion Company: AstraZeneca First FDA Approval: January 13, 2014 Indications: Type 2 diabetes, type 1 diabetes, heart failure Farxiga is a novel, once-daily oral sodium-glucose co-transporter 2 (SGLT2) inhibitor

NICE guidance on obesity principally NICE CG189 (Obesity: identification, assessment and management) and NICE PH53 (Weight management: lifestyle services for overweight or obese adults) recommends a combination of dietary modification, increased physical activity, and behavioural support as the cornerstone of weight management