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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

They can help figure out whats going on (like if youre taking doses that are too high or if another supplement is interfering with your B12 levels) and help you figure out the best course of action

Existing literature points strongly to 5-Amino-1MQ