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The tissue has become more stable, more resistant to change

Mice have fundamentally different gut microbiome compositions than humans

J Integr Agric 12(3):502508 Rahman MM, Fetouh FA (2013) Effect of sodium fluoride on the thyroid follicular cells and the amelioration by calcium supplementation in albino rats: a light and an electron microscopic study

If thats true, it raises a question that extends well beyond any single medication: how many conditions we treat as separate diseases are actually the same disrupted network showing up in different places