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Excessive nitric oxide levels may react with superoxide to produce peroxynitrite

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In ALS, the dysfunctional uptake of glutamate by astrocytic transporters contributes to excitotoxicity at least in a subset of ALS patients [97], however, simple inhibition of glutamate transport failed to produce an ALS-like condition in animals (see section The classical view: microglia as engines of inflammation for more details)