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A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans
Heerspink HJL, Oshima M, Zhang H et al (2022) Canagliflozin and kidney-related adverse events in type 2 diabetes and CKD: findings from the randomized CREDENCE trial
We also translate the cardiovascular story into human termswhy some large trials found fewer heart attacks and strokes and give a reality-check on the brain research so you know whats hopeful and whats hype
Mechanistically, it acts as a ghrelin mimetic, binding the growth hormone secretagogue receptor (GHS-R1a) the receptor for the endogenous peptide ghrelin, expressed in the pituitary and hypothalamus
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