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Long-term follow-up of patients has not validated these concerns

The firm witnessed remarkable growth in 2022, thanks to numerous novel drug developments, including Spevigo (spesolimab) for pustular psoriasis, Jardiance (empagliflozin) for chronic heart failure and Ofev (nintedanib) for respiratory diseases

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Although one mole of ATP is used by hexokinase and an additional mole of ATP by phosphofructokinase, the net gain is 2 moles of ATP per mole of glucose, because a total of 4 moles of ATP is formed per mole of glucose by phosphoglycerate kinase and pyruvate kinase