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For severe allergic reactions (anaphylaxis): Emergency treatment includes: Intramuscular adrenaline (epinephrine) 500 micrograms (0.5ml of 1:1000) into the anterolateral thigh this is the first-line and most important treatment High-flow oxygen and airway management Intravenous fluids for circulatory support Antihistamines may be given for persistent skin symptoms but are not first-line treatment for anaphylaxis Hospital observation with duration based on risk assessment (minimum 2-6 hours for uncomplicated cases