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Therapeutic advances in musculoskeletal disease

On the basis of results of the most recent CVOTs (DAPA-HF, DAPA-CKD, EMPEROR-R), the FDA has approved dapagliflozin (2020) and empagliflozin (2021) to reduce risk for CV death and HF hospitalization in adults with HF and reduced ejection fraction regardless of whether they have diabetes [24, 25]

This is the application area with the deepest preclinical history, and it is also where oral administration has a particularly direct anatomical rationale - the compound passes through the GI tract it was originally studied in relation to

Werden SGLT-2-Inhibitoren nicht vertragen oder besteht eine Kontraindikation oder die eGFR ist nicht mehr ausreichend, sollten an ihrer Stelle GLP-1 RA eingesetzt werden