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A deficiency can occur for several reasons, such as pernicious anemia (a condition where the body cannot absorb vitamin B12 from the diet), certain medical conditions (e.g., Crohn's disease, celiac disease), surgical removal of part of the stomach or intestine, or strict vegetarian/vegan diets if not adequately supplemented

The peptide signals tissue remodeling, collagen and elastin synthesis, and gene expression linked to wound repair

Pandey M, Choudhury H, Segar Singh SK et al (2021) Budesonide-loaded pectin/polyacrylamide hydrogel for sustained delivery: fabrication, characterization and in vitro release kinetics