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Rare but serious side effects have been reported, including liver injury and kidney stones (oxalate nephropathy)

As documented in the peer-reviewed literature, GSH serves as a cofactor for glutathione peroxidase (GPx) and glutathione S-transferase (GST), and plays a central role in cellular redox homeostasis (ncbi.nlm.nih.gov, pmc.ncbi.nlm.nih.gov)

Second, a break is a natural checkpoint: it lets a researcher assess where things stand off-compound before deciding whether to re-run