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In the context of Alzheimer's disease, the excessive and uncontrolled generation of superoxide by microglial NADPH oxidase contributes to significant oxidative damage, directly contributing to neurodegeneration and cognitive impairment ( 6.4 Inflammatory cytokines and mitochondrial damage Dysregulated microglial function plays a key role in various neurodegenerative, autoimmune, and viral diseases, such as Alzheimer's and Parkinson's disease

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