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10.1097/WNF.0000000000000299 330 Monteiro-CardosoV

Constitutive and -naphthoflavone-induced expression of the human -glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

Furthermore, evidence shows that most (up to 95%) pharmaceutical drugs found effective and safe in animal studies fail in subsequent clinical phases in human populations, mainly due to insufficient efficacy, toxicity, and the emergence of unacceptable adverse drug reactions, raising significant concerns for ethical and economic reasons (204211)

Inhibition of adenosine A1 receptors abolished the nutritional ketosis-evoked delay in the onset of isoflurane-induced anesthesia in Wistar Albino Glaxo Rijswijk rats