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Conclusions This review of published studies indicates that evidence for the involvement of the -glutamyl cycle and trans-sulphuration pathway in autism spectrum disorders should be further explored with higher quality and lower risk bias studies to in order to ascertain the significance of these pathways with respect to clinical outcomes

Significant allergic reactions, though rare, require stopping use and potentially seeking medical attention

Taking glutathione the morning after when acetaldehyde is already cleared addresses oxidative damage but wont reverse symptoms that are neurological or hydration-related

Some peptides stabilize neuronal membranes, reduce oxidative stress, or modulate excitotoxic signaling that kills vulnerable neurons during the recovery period