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Hcy-thiolactone/creatinine ratio was indicated as a novel acute myocardial infarction risk predictor in patients with suspected coronary artery disease, independent of traditional risk factors and Hcy, but modified by vitamin B6 catabolism 9

DNA damage as measured by poly-ADP ribose polymerase (PARP) activity has also been shown to be elevated between 1 and 21 days after CCI injury in adult rodents (Satchell et al., 2003)