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For people with severe renal impairment (eGFR below 30 mL/min/1.73 m) or those on dialysis, the evidence base for most weight loss medications is limited, and many are either contraindicated or lack sufficient safety data

In one clinical experiment, patients treated with NAC had higher multivariate phase synchronisation, which changed neuron connectivity in the brain, as evaluated by an electroencephalogram, even before any clinically noticeable improvement [36]

Ethics declarations Competing interests RS and JPR received research funding for this study from Researched Nutritionals, LLC