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When regulators determine that the temporary phase has concluded, the resulting shift can be abrupt, disproportionately affecting platforms reliant on scale

Copper is a cofactor for lysyl oxidase (the enzyme that crosslinks collagen and elastin), superoxide dismutase (a critical antioxidant enzyme), and numerous other copper-dependent enzymes involved in tissue maintenance

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Three specific arginine to cysteine substitutions (Arg312Cys, Arg574Cys, and Arg1093Cys) of COL1A1 have been observed in cases described to have vEDS with a more cEDS-like presentation, vascular-like EDS, classic vascular-like EDS, and cEDS only (Arg312Cys)