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When mucins are released into the airway, the proteins, which were tightly packed due to electrostatic interactions between the negatively-charged mucins, calcium, and hydrogen ions, begin to unfurl through replacement of the calcium with sodium ions and are swept along the epithelium by ciliary beating (Kesimer et al., 2010

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B.Garcia-VerdugoI.MedinaM.BalloyV.ChignardM.RamphalR.et al (2012)