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i.p) has been shown to result in an increase in glutamate in the extracellular space by binding to astrocytic CB 1 Rs in mice, contributing to long term depression at synapses and impairments in working memory (Navarrete and Araque, 2010

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In summary, ACSL4 not only offers a potential therapeutic avenue to induce tumor cell ferroptosis, but also serves as a pivotal determinant of ferroptosis sensitivity in radiation-induced brain injuries

Rare but serious concerns reported include pancreatitis and gallbladder events