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This induction often occurs via activation of Nrf2 (Nuclear factor erythroid 2-related factor 2), a key transcription factor in the antioxidant response pathway

Lysosomes contain approximately 60 different soluble hydrolases that hydrolyze glycosaminoglycans, phospholipids, and a range of proteins, and cytosolization results in the release of a large number of stored substances from secreted lysosomes (80)

As with other medicines in this class, potential class-related risks including gallbladder events, pancreatitis, and small increases in resting heart rate are being evaluated in ongoing studies

More than 10 years ago, a compounding pharmacy in Massachusetts produced contaminated steroid spinal injections, in bulk, that resulted in a widespread fungal meningitis outbreak, injuring more than 700 patients and killing 100