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Although the exact mechanism of ADE remains to be understood, ADE has been reported to take place in two possible ways, first, internalization of virusantibody immune complexes into phagocytic cells via interaction of the antibody Fc region with the cellular Fc receptors present on myeloid cells which then render immune system to trigger signal transduction, releasing inflammatory cytokines, superoxide burst, and antibody-dependent cell-mediated cytotoxicity (ADCC) leading to the heightened antibody-mediated uptake of the virus 27,38,55 (Fig

Accessories to the crime: functions of cells recruited to the tumor microenvironment

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