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Safety Profile, Side Effects, and Contraindications MOTS-c has a favorable safety profile in the published research to date, which is unsurprising given that it is an endogenous peptide that naturally circulates in human blood

You are testing whether the medications, side effects, costs, adherence burden (how many pills you cumulatively have to pop each day), and long-term medicalisation are justified by the likely absolute benefit

Its often used alongside glucosamine, chondroitin, omega-3s, and even NSAIDs

These include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and specific 5-hydroxytryptamine antidepressants, as well as benzodiazepines (Zelek-Molik and Litwa, 2025)