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Some patients maintain clinically meaningful weight loss at semaglutide 1.0 mg or tirzepatide 5 mg rather than the labeled maximum

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Chronic weight management remains sizable, supported by employer programs and increasing social acceptance that obesity is a chronic disease requiring pharmacotherapy

Consistent with EWGSOP2, sarcopenia should be understood as a progressive skeletal muscle disorder defined primarily by low muscle strength, with reduced muscle quantity or quality used to confirm the diagnosis, and poor physical performance indicating severe disease