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It also restores synovial joint lubrication, repairs joint cartilage, reverses the disease cycle, and reduces inflammation

However, under pathological states such as obesity, chronic inflammation, and mitochondrial dysfunction, impaired BCAA catabolism leads to accumulation, participating in the pathogenesis and progression of insulin resistance, type 2 diabetes, cardiovascular disease, and sarcopenia through multiple mechanisms including excessive mTORC1 activation, insulin signaling interference, and mitochondrial stress induction

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