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Cortisol has a well-defined 24-hour circadian rhythm

Many T2D patients have antibodies to insulin, which makes them insensitive to insulin and results in their cells not taking up sufficient glucose and therefore results in insufficient energy metabolism

Anand U, Yiangou Y, Akbar A, Quick T, MacQuillan A, Fox M et al (2018) Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons

These higher-dose protocols have not been evaluated in human clinical trials, so there is no evidence that they are more effective than standard protocols