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This population-specific safety evidence is more relevant for clinical application than data from exclusively healthy volunteers would be
A fancy brand promising a high dosage like 1000mg might still be less effective if your body can't properly absorb it, or if that dose requires multiple pills per serving, making it much more expensive in the long run
Its discovery opened new avenues for understanding how mitochondria communicate with the rest of the cell to regulate systemic metabolism
They might not want to go out or exercise because they're scared of leaking
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