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Studies have shown that caffeic acid can inhibit the expression of Keap1, reduce the stabilization of the Keap1 and Nrf2 complex, thereby activate Nrf2 and upregulate the expression of downstream antioxidant enzymes NQO1 and HO-1 (Pang et al., 2016)

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The pulmonary resistance continues to decrease until reaching the normal adult ratio of 1:10 by 4-8 weeks (see figure)

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