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In the intestinal host cells, indoleamine and tryptophan 2,3-dioxygenases (IDO/TDO) activate the kynurenine (KYN) pathway, generating KYN metabolites, many of which activate aryl hydrocarbon receptor (AhR) signaling

doi: 10.1016/j.tranon.2021.101056 26 WangSGuoSGuoJDuQWuCWuYet al

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