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10.1186/s12967-024-06016-7 J Transl Med

This suggests that the progressive accumulation of lipids in the liver, which would trigger increased insulin secretion, and the accumulation of lipids in the pancreas, which would eventually lead to a reduction in -cell function, play a central pathogenetic role in the development of T2D [25]

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One of his earliest wake-up calls came during a doctors visit, when the office scale couldnt accommodate him and he was told hed need to visit a truck stop or meat processor to get an accurate weight