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The acquired resistance to ICB treatment might be due to cancer cell-intrinsic and -extrinsic changes, including the loss of MHC class I on cancer cells (175, 176), genetic mutations that diminish T-cell infiltration (177, 178), or host microbiota (179182)

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Direct measurement of iron levels with inductively-coupled plasma mass spectrometry showed that the iron-fed group had markedly elevated iron levels and the amlodipine group had significantly reduced iron levels (Figure 1C)

Tumor cells undergo metabolic reprogramming to adapt to rapid proliferation and harsh microenvironment