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As a result, any microparticle formulation cannot deliver molecular drug directly to the epithelial cells where initial infection takes place because of the protective mucin barrier that is produced by, and covers, these cells (41)
Thus, quenching of excess ROS is very necessary to counter their deleterious effects
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Although we performed multivariate adjustments, residual confounding may persist due to unmeasured factors such as dietary habits (e.g., irregular intake of animal-derived foods or B12-fortified products), unrecorded use of nutritional supplements, and genetic predispositionsparticularly MTHFR polymorphisms, which are known to influence homocysteine metabolism and folate cycling, thereby potentially altering the functional demand for vitamin B12
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