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This observed dysregulation of the autonomous nervous system has implications in the treatment of CVS, such as vagal neuromodulation with percutaneous electrical nerve field stimulation,31 which improves symptoms, modulating the vagal function in patients with gut-brain axis gastrointestinal disorders and those with CVS.32 In addition, neuromodulation has been shown to predominantly benefit the subgroup of patient that have deficient vagal function.33 Allostasis Homeostasis cannot completely explain the autonomic changes that accompany purely cognitive and emotional events

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As shown in Figure 5 , a total of 230 differential metabolites were screened in the NC, FI and GSH groups