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are employees of Shimadzu, Kyoto, Japan

5.1 Mechanism of intranasal delivery Since William Frey II proposed intranasal administration in 1991 (Frey, 1991), this technique has emerged as a novel, non-invasive delivery system, bypassing the BBB and the systemic first-pass effect, allowing rapid onset of action

These 17 amino acids are: histidine, alpha-aminoisobutyric acid, glutamic acid, glycine, threonine, phenylalanine, serine, aspartic acid, valine, tyrosine, leucine, glutamine, alanine, lysine, isoleucine, tryptophan, and arginine

The protective role of IF during inflammation in enhancing intestinal barrier function is accomplished through two main mechanisms