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Safety and Research Limitations Importantly, No adequate clinical evidence defines safe human exposure, maximum tolerated dose, reproductive toxicity, carcinogenicity, genotoxicity, cardiovascular risk, liver safety, kidney safety, endocrine effects, or drug interactions

doi: 10.1177/1040638717711995

doi: 10.3389/fspor.2025.1462901 Dhakal A, Sbar E

Other medications including: Environmental toxins Toxins in the environment like pollutants and pesticides can lead to increased intestinal permeability: Pollutants like pesticides, heavy metals, and industrial-grade chemicals can lead to toxicity in the gastrointestinal tract, damaging the intestinal lining and causing a leaky gut