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The Overlapping Biology of Addiction and Obesity Research shows SUDs share biological and psychological similarities with overeating and obesity, with both involving dysregulation of the brains reward system (Srinivasan et al., 2025)

We recognize that successful weight loss involves more than just medication, which is why our approach goes beyond offering semaglutide

In future work, it would be interesting to investigate if GHS-R1a antagonists may suppress craving and prevent relapse by its actions in the ventral hippocampus or the amygdala