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Read about metformin and its role in healthy aging

References 1.Kraemer W.J., Volek J.S., Dunn-Lewis C

Increased adiponectin also reduces blood glucose levels and improves insulin sensitivity, appetite control, central fat distribution (smaller waist size) as well as muscle regeneration, thus acting as a protective factor to prevent loss of muscle mass

Es posible que el aumento de la actividad fsica, permitido por la prdida sustancial de peso, pueda dar lugar a la aparicin de sntomas articulares que antes estaban enmascarados por la inactividad