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External factors include temperature fluctuations, bright lights, loud noises, and strong odors, while internal triggers encompass anxiety, emotional stress, insomnia, specific foods, and inadequate blood glucose supply (4)

neoformans induce a strong non-protective Th2 response as demonstrated by an increased accumulation of eosinophils in the lung, increased serum IgE and higher levels of Th2 cytokines [288], demonstrating a role for urease in influencing the host immune response