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Shestakova, E

Abbreviations ER endoplasmic reticulum PDH pyruvate dehydrogenase TCA tricarboxylic acid CPT1 carnitine palmitoyltransferase 1 TMAO trimethylamine N-oxide OCTN2 organic cation transporter novel 2 BBB blood-brain barrier PCD primary carnitine deficiency FAO fatty acid oxidation CPT2 carnitine palmitoyltransferase 2 CAT carnitine acetyltransferase INF- interferon TNF- tumor necrosis factor- IDH1 isocitrate dehydrogenase 1 ROS reactive oxygen species PPAR peroxisome proliferator-activated receptor PPAR peroxisome proliferator-activated receptor GBM glioblastoma ER+ estrogen receptor positive CRC colorectal cancer OCT organic cation transporter IngMeb ingenol mebutate

Composition and method-of-treatment patents, followed by formulation and device patents that complicate substitution and labeling