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The study also found sustained, dose-dependent GH and IGF-1 increases

Strategies to mitigate lean muscle loss while on treatment include optimising dietary protein, recognising that GLP-1 and GIP/GLP-1 receptor agonists may suppress appetite and substantially reduce overall energy intake, increasing the risk of inadequate protein consumption.260-262 Regular resistance exercise training can help preserve lean muscle mass during weight loss and should be performed on two or more days per week, where clinically appropriate.159 Dietary advice for people on incretin-based medications Incretin-based medications increase the risk of muscle loss, sarcopenic obesity and nutrient deficiencies

During a caloric deficit, your muscles need a stimulus that tells the body to keep them

Growth Hormone & IGF Research (1999) 10