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Sources: Novo Nordisk

TABLE 3 Summary of carbon quantum dot (CQD) in vitro cytotoxicity in mammalian cell lines

For example, in various cell culture lines, c-Met phosphorylation can result in downstream activation of Akt, Erk/MAPK, JNK, or FAK signaling (reviewed by Organ and Tsao, in vitro and in vivo (Cunningham et al., Understanding hair cell death mechanisms activated by specific ototoxins can help shed light on what molecular signals to therapeutically target for each toxic agent

Results demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, the peptide produced no clinically significant alterations in IGF-1 levels, no glucose intolerance or insulin resistance, and no anti-AOD9604 antibodies in any participant